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In vitro pharmacological properties of 4-bromodexetimide for muscarinic receptors.
Strijckmans V, Coulon C, Kassiou M, Loc'h C, Mazière B. Strijckmans V, et al. Life Sci. 1996;58(23):PL337-44. doi: 10.1016/0024-3205(96)00212-3. Life Sci. 1996. PMID: 8649190
The decrease of m-AChR density observed in neurodegenerative disorders has generated considerable interest in non-invasive mapping of muscarinic acetylcholine receptors (m-AChR) in the central nervous system. The aim of our study was to evaluate the se …
The decrease of m-AChR density observed in neurodegenerative disorders has generated considerable interest in non-invasive map …
Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomography.
McPherson DW, DeHaven-Hudkins DL, Callahan AP, Knapp FF Jr. McPherson DW, et al. J Med Chem. 1993 Apr 2;36(7):848-54. doi: 10.1021/jm00059a009. J Med Chem. 1993. PMID: 8464039
1-Azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)- alpha-phenylacetate (IQNP, 3), an analogue of QNB in which a phenyl ring has been replaced with an iodopropenyl substituent, was prepared and evaluated in vitro and in vivo for m-AChR selectivit …
1-Azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)- alpha-phenylacetate (IQNP, 3), an analogue of QNB in which a phenyl …
The in vitro dissociation kinetics of (R,R)-[125I]4IQNB is reflected in the in vivo washout of the radioligand from rat brain.
Gibson RE, Moody T, Schneidau TA, Jagoda EM, Reba RC. Gibson RE, et al. Life Sci. 1992;50(9):629-37. doi: 10.1016/0024-3205(92)90249-o. Life Sci. 1992. PMID: 1740971
Following intravenous injection, (R,R)-[125I]4IQNB binds to receptor in the rat brain in concentrations which reflect the receptor concentration present in a structure. We determined the extent of radioligand present at two times, 2 and 24 hrs, as an indication of the rela …
Following intravenous injection, (R,R)-[125I]4IQNB binds to receptor in the rat brain in concentrations which reflect the receptor co …